Heat shock proteins increase during a race with high exertional heat stroke incidence

Autor: Virgilio Lopez III, Yuri Hosokawa, Yasuki Sekiguchi, Skylar N. Wright, Zoha Sarwat, Joseph J. Bivona, Staci N. Thornton, Ekow Dadzie, Cyrus Brown, Anupama Dwarki, John F. Jardine, William M. Adams, Douglas J. Casa, Elane C. Lee
Rok vydání: 2023
Popis: Background: Circulating heat-inducible, heat-shock protein 72 [HSP72] responses to exercise-heat stress have been well studied as a potential biomarker of exertional heat illness susceptibility. However, little is known about the responses of other HSPs important to immune responses and pathophysiology. HSP27, -60, and -90 are fundamental HSPs important in cellular proteostasis and pathophysiology associated with immune dysregulation. Therefore, we aimed to characterize responses of HSP27, -60, and –90 during a race known to introduce extreme levels of exercise-heat stress that annually result in high incidences of exertional heat stroke. Methods: Thirty participants (45.3±11.7 yr, 175.6±8.9 cm, 74.9±13.5 kg, 19.7±3.6 % body fat) registered to run in the Falmouth Road Race (Falmouth, MA) were recruited. Gastrointestinal temperature (TGI) and blood plasma HSP27, -60, and -90 (by commercially available ELISA) were measured at pre- (PRE) and post-race (POST). Results: TGI, [HSP27], and [HSP90] increased at POST (pGI at POST (p>0.05). In conclusion, HSPs are important for constitutive cellular function and measurably increase circulation post-exercise-heat stress. Correlation between HSPs and pre- or post-event core temperature to determine utility as predictive biomarkers require further study.
Databáze: OpenAIRE