Man-made antibodies and immunoconjugates with desired properties: function optimization using structural engineering

Autor:	Lada E. Petrovskaya, E. N. Lebedenko, Dmitry A. Dolgikh, Mikhail P. Kirpichnikov, Sergey M. Deyev, Alexander G. Gabibov
Rok vydání:	2015
Předmět:	Modular structure medicine.drug_class Function optimization Chemistry medicine.medical_treatment medicine Nanotechnology General Chemistry Computational biology Monoclonal antibody Targeted therapy
Zdroj:	Russian Chemical Reviews. 84:1-26
ISSN:	1468-4837 0036-021X
Popis:	The review outlines progress and problems in the design of non-natural antibodies for clinical applications over the past 10–15 years. The modular structure of natural antibodies and approaches to its targeted modifications and combination with other structural elements and effector molecules are considered. The review covers modern methods for immunoglobulin engineering and promising strategies for the creation and applications of monoclonal antibodies, their derivatives and analogues, including abzymes and scaffolds, oriented to the use in the diagnosis and targeted therapy of cancer and other socially significant diseases. The bibliography includes 225 references.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56e8b27305a507b0d27e6efbf98dac6b https://doi.org/10.1070/rcr4459 Zobrazit plný text záznamu