| Autor: |
Ruggero Fumarulo, Michele Aresta |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Inorganica Chimica Acta. 137:99-103 |
| ISSN: |
0020-1693 |
| DOI: |
10.1016/s0020-1693(00)87125-x |
| Popis: |
The in vitro effects of cisplatin on human polymorphonuclear functions were studied in order to establish if the drug is able, during chemotherapy, to induce an immune depression of host response and an increased susceptibility to infections. All the phagocytic functions tested were negatively influenced, but only chemotaxis was really depressed by cisplatin used in therapeutic concentrations (from 10−5 to 10−6 M). This finding was confirmed in chemotactic tests performed on leukocytes elicited from cancer patients after cisplatin intravenous administration. The binding to the tubulin sulfhydryl groups and the inhibition of microtubule polymerization have been proposed to explain how the drug affects cytoskeleton activities. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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