Structural Requirements for the Antiprotozoal Activity of 4-Aminobicyclo[2.2.2]octan-2-ols
| Autor: | Heinrich Berger, Robert Weis, Werner Seebacher, Marcel Kaiser, Reto Brun, Robert Saf |
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| Rok vydání: | 2006 |
| Předmět: |
biology
Bicyclic molecule Chemistry medicine.drug_class Stereochemistry Plasmodium falciparum General Chemistry biology.organism_classification Protozoan parasite chemistry.chemical_compound Causative organism parasitic diseases Trypanosoma Antiprotozoal medicine Structure–activity relationship Octane |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 137:471-482 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-006-0455-7 |
| Popis: | Several 4-aminobicyclo[2.2.2]octan-2-ones and -ols were synthesized using different pathways. The new compounds were investigated for their activity against Trypanosoma b. rhodesiense, the causative organism of East African sleeping sickness and Plasmodium falciparum the protozoan parasite which causes Malaria tropica. The results are compared to the activities of known compounds and the influence of the substitution of the bicyclo[2.2.2]octane skeleton on the biological activities is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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