Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra

Autor: Raymond Cooper, Phyllis Speight, Colin J. Barrow, Amanda M. Gillum, Susan McElhiney, Loran M. Killar, Laszlo L. Musza
Rok vydání: 1994
Předmět:
Zdroj: Tetrahedron. 50:11369-11378
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)89279-6
Popis: A series of seco-limonoids, with uncommon hemi ortho ester A-rings, was isolated from the root of Trichilia rubra. Their structures were determined by extensive spectroscopic studies. The five new and two previously known compounds were all found to be potent inhibitors of LFA-1:ICAM-1 mediated cell adhesion.
Databáze: OpenAIRE