Radiation preparation of drug carriers based polyacrylic acid (PAAc) using poly(vinyl pyrrolidone) (PVP) as a template polymer
| Autor: | El-Sayed A. Hegazy, N.A. Hamed, F.H. Khalil, H. A. Abd El-Rehim |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Nuclear and High Energy Physics Polyacrylic acid technology industry and agriculture macromolecular substances Polymer Microstructure chemistry.chemical_compound chemistry Chemical engineering Polymerization Drug delivery Polymer chemistry medicine Swelling medicine.symptom Drug carrier Instrumentation Dissolution |
| Zdroj: | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 254:105-112 |
| ISSN: | 0168-583X |
| Popis: | The present study deals with the radiation synthesis of stimuli response hydrophilic polymers from polyacrylic acid (PAAc). To maintain the property of PAAc and control the water swellibility for its application as a drug delivery system, radiation polymerization of AAc in the presence of poly(vinyl pyrrolidone) (PVP) as a template polymer was carried out. Characterization of the prepared PAA/PVP inter-polymer complex was investigated by determining gel content, swelling property, hydrogel microstructure and the release rate of caffeine as a model drug. The release rate of caffeine from the PAA/PVP inter-polymer complexes showed pH-dependency, and seemed to be mainly controlled by the dissolution rate of the complex above a pKa of PAAc. The prepared inter-polymer complex could be used for application as drug carriers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect