New 2-fluoro 8α-analogs of steroidal estrogens

Autor:	S. N. Morozkina, Stanislav I. Selivanov, A. F. Fidarov, A. G. Shavva
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Fluorine Organic chemistry chemistry.chemical_element Ether
Zdroj:	Russian Journal of Organic Chemistry. 50:1520-1526
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428014100182
Popis:	New 8α-analogs of steroidal estrogens containing a fluorine atom in the 2-position have been synthesized with the goal of obtaining modified derivatives with improved biological characteristics. Some of the synthesized compounds have been found to display improved ratio of the osteoprotective and uterotropic effects. 2-Fluoro-16,16-dimethyl-d-homo-8α-estrone and its methyl ether exhibit hypocholesterolemic and cardioprotective activity and no uterotropic effect.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56ca6cb6f31318627eac44f809202803 https://doi.org/10.1134/s1070428014100182 Zobrazit plný text záznamu Plný text ve formátu PDF