Setting of reliable immunohistochemical criteria for the recurrence of nodular basal cell carcinoma

Autor: N.Yu. Orlinskaya, D.V. Davydenko, O. E. Garanina, I.L. Shlivko
Rok vydání: 2020
Předmět:
Zdroj: CLINICAL AND EXPERIMENTAL MORPHOLOGY. 9:43-49
ISSN: 2686-6749
2226-5988
DOI: 10.31088/cem2020.9.3.43-49
Popis: Introduction. Basal cell carcinoma (BCC) is one of the most prevalent skin neoplasms with increasing incidence. The grade of BCC malignancy is highly variable and depends on the invasiveness and recur-rence potential. The study was aimed at identification of immunohistochemical (IHC) determinants of BCC recurrence. Materials and methods. The comparative study encompassed 10 cases of primary BCC and 10 cases of recurrent BCC. The panel of immunohistochemical targets included p53, CK8/18, Bcl-2, CK19, Collagen type IV, Desmin, CD8, Ki-67, Vimentin, VEGFR, EGFR and AR. Results. Diffuse expression of vimentin (characteristic of both primary and recurrent BCCs and clearly indicating the border between the tumor stroma and the surrounding dermis) in the recurrent tumors was twice as strong as in the primary tumors. Immunohistochemistry for collagen type IV revealed different nature of the basement membrane alterations in the primary and recurrent tumors. A two-fold increase in the intensity of angiogenesis observed in the recurrent tumors was accompanied by a more than two-fold significant increase in the androgen receptor protein expression. Conclusion.Increasing grade of BCC malignancy is associated with the immunohistochemically revealed reinforcement of the stromal and vascular components of the tumor, as well as progressive destruction of the basement membrane along with the increased expression of androgen receptor protein by tumor cells. Keywords: basal cell carcinoma, recurrence, immunohistochemistry
Databáze: OpenAIRE
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