Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products
| Autor: | Cornelia H. de Moor, Peter A. D. Wellham, Dong-Hyun Kim, Matthias Brock |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0303 health sciences Cordyceps biology Cordycepin Traditional medicine Ophiocordyceps sinensis General Medicine Fungus biology.organism_classification 01 natural sciences Conidium 03 medical and health sciences chemistry.chemical_compound chemistry Biosynthesis Cordyceps militaris medicine Pentostatin 030304 developmental biology 010606 plant biology & botany medicine.drug |
| Zdroj: | Annals of Translational Medicine. 7:S85-S85 |
| ISSN: | 2305-5847 2305-5839 |
| DOI: | 10.21037/atm.2019.04.25 |
| Popis: | Cordycepin, or 3'-deoxyadenosine, is a metabolite produced by the insect-pathogenic fungus Cordyceps militaris and is under intense investigation as a potential lead compound for cancer and inflammatory conditions. Cordycepin was originally extracted by Cunningham et al. (1) from a culture filtrate of a C. militaris culture that was grown from conidia. Subsequently, cordycepin has also been reported to be produced by Ophiocordyceps sinensis (2), a species historically used as a traditional medicine and health food, primarily in China and the wider Far East (3). Cultivated C. militaris is now widely in use as less expensive substitute. In addition, these fungi are also globally gaining a market as natural food supplements, with 30–50 products claiming to contain Cordyceps available in the UK and the USA. |
| Databáze: | OpenAIRE |
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