Effect of stem cell inhibition factor and macrophage micration inhibition factor on exocolonization and migration of mouse spleen cells

Autor:	E. B. Mysyakin, A. P. Suslov, T. A. Golovanova, D. R. Kaulen
Rok vydání:	1978
Předmět:	Chemistry Hematopoietic stem cell Spleen General Medicine Molecular biology General Biochemistry Genetics and Molecular Biology In vitro Migration inhibition factor medicine.anatomical_structure Immunology medicine Macrophage Bone marrow Stem cell Incubation
Zdroj:	Bulletin of Experimental Biology and Medicine. 86:1221-1224
ISSN:	1573-8221 0007-4888
Popis:	Hematopoietic stem cell inhibition factor (SCIF), liberated by lymphocytes treated with antilymphocytic globulin, causes inhibition of migration of the spleen cells of intact mice. The degree of inhibition of migration corresponds to the colony-inhibiting activity of the SCIF. Macrophage migration inhibition factor (MMIF) obtained in the H-2 system has a stimulating effect on exocolonization in mice on treatment of a bone-marrow graft in vitro. The colony-stimulating activity of MMIF corresponds to its inhibitory effect on migration of spleen cells. Incubation of bone marrow cells with MMIF for 30 min is more effective than incubation for 2 h. It is suggested that SCIF and MMIF are not identical with one another.
Databáze:	OpenAIRE
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