Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes
| Autor: | Tarig Babiker, Siri Atma W. Greeley, Pamela Bowman, Sarah E. Flanagan, Jacques Beltrand, Fabrizio Barbetti, Janine Sanchez, Eamon Rawlins, Lisa R. Letourneau-Freiberg, Andrew T. Hattersley, Nicholas J. Thomas, Maggie Shepherd, Barbara Piccini, Michel Polak, Elisa De Franco, Sian Ellard, Frances Mathews |
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| Rok vydání: | 2020 |
| Předmět: |
Advanced and Specialized Nursing
Pediatrics medicine.medical_specialty business.industry medicine.drug_class Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment 030209 endocrinology & metabolism Hypoglycemia medicine.disease Sulfonylurea 3. Good health 03 medical and health sciences 0302 clinical medicine Neonatal diabetes mellitus Diabetes mellitus Internal Medicine medicine Attention deficit hyperactivity disorder 030212 general & internal medicine business Adverse effect Glycemic |
| Zdroj: | Diabetes Care. 44:35-42 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc20-1520 |
| Popis: | OBJECTIVE ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ∼90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included combinations of ABCC8-PNDM and ABCC8-TNDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM. RESEARCH DESIGN AND METHODS We studied all 24 individuals with ABCC8-PNDM diagnosed in the U.K., Italy, France, and U.S. known to transfer from insulin to sulfonylureas before May 2010. Data on glycemic control, sulfonylurea dose, adverse effects including hypoglycemia, and neurological features were analyzed using nonparametric statistical methods. RESULTS Long-term data were obtained for 21 of 24 individuals (median follow-up 10.0 [range 4.1–13.2] years). Eighteen of 21 remained on sulfonylureas without insulin at the most recent follow-up. Glycemic control improved on sulfonylureas (presulfonylurea vs. 1-year posttransfer HbA1c 7.2% vs. 5.7%, P = 0.0004) and remained excellent long-term (1-year vs. 10-year HbA1c 5.7% vs. 6.5%, P = 0.04), n = 16. Relatively high doses were used (1-year vs. 10-year dose 0.37 vs. 0.25 mg/kg/day glyburide, P = 0.50) without any severe hypoglycemia. Neurological features were reported in 13 of 21 individuals; these improved following sulfonylurea transfer in 7 of 13. The most common features were learning difficulties (52%), developmental delay (48%), and attention deficit hyperactivity disorder (38%). CONCLUSIONS Sulfonylurea treatment of ABCC8-PNDM results in excellent long-term glycemic control. Overt neurological features frequently occur and may improve with sulfonylureas, supporting early, rapid genetic testing to guide appropriate treatment and neurodevelopmental assessment. |
| Databáze: | OpenAIRE |
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