| Autor: |
Martac Ljiljana, Nikolic-Judith Anna, Culic Milka, N Todorovic Vera, Grbic Gordana, Kalauzi Aleksandar, C Drndarevic Neda, Z Spasic Sladjana |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Acta veterinaria. 52:299-304 |
| ISSN: |
0567-8315 |
| DOI: |
10.2298/avb0206299c |
| Popis: |
Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
