Urinary Excretion of Metoclopramide after Intravenous Infusion and Oral Administration

Autor:	Hideyuki Murota, Shigeru Yamazaki, Katsuo Unno
Rok vydání:	1980
Předmět:	Excretion Urinary excretion Metoclopramide Injection Metoclopramide business.industry Oral administration Anesthesia medicine Urine business Crossover study Fasting state medicine.drug
Zdroj:	Japanese Journal of Hospital Pharmacy. 6:192-195
ISSN:	2185-9477 0389-9098
Popis:	Single dose (10mg) of metoclopramide injection, syrup and tablet was given in crossover design to 3 healthy male volunteers in the fasting state. Excretion of metoclopramide into urine was determined by spectrophotometry. Urinary excretion of metoclopramide 24 hours after administration of syrup was 77.7% and that of tablet 91.0%, as against the excretion after intravenous infusion as 100%. Urinary excretion of N4-glucuronide was larger by oral administration than by intravenous infusion, and unchanged metoclopramide was excreted more by intravenous infusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56b6117b92f2e9ba9373ef52aa0f5105 https://doi.org/10.5649/jjphcs1975.6.192 Zobrazit plný text záznamu