Hypolipidemic activity of Anthocephalus indicus (kadam) in hyperlipidemic rats
| Autor: | Vishnu Kumar, Mohammad Mubin Khan, Ramesh Chander, Ashok Kumar Khanna, Farzana Mahdi, Sushma Singh, Ranjana Singh, Raj Kumar Singh, Jitendra Kumar Saxena |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Guggulipid Rubiaceae biology Traditional medicine Triglyceride Organic Chemistry Pharmacology toxicology Stimulation Plasma levels biology.organism_classification chemistry.chemical_compound Endocrinology chemistry Internal medicine Total cholesterol medicine General Pharmacology Toxicology and Pharmaceutics Anthocephalus |
| Zdroj: | Medicinal Chemistry Research. 17:152-158 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-007-9045-4 |
| Popis: | The hypolipidemic action of Anthocephalus indicus (family, Rubiaceae: Hindi name, Kadam) fruit extract has been studied in hyperlipidemic rats fed a triton- and cholesterol-rich high-fat diet. In triton WR-1339-induced hyperlipidemic rats, feeding with the fruit extract (500 mg/kg b.w.) exerted a lipid-lowering effect as assessed by reversal of plasma levels of total cholesterol, phospholipids, and triglyceride following reactivation of the post-heparin lipolytic activity. In another model, chronic feeding of this natural product (500 mg/kg, b.w.) to animals simultaneously fed a high-fat diet for 30 days caused lowering of lipid levels in plasma and liver accompanied with stimulation of hepatic lipolytic activity. The hypolipidemic activity of Anthocephalus indicus fruit extract iscompared with guggulipid, a known lipid-lowering drug, in both models. |
| Databáze: | OpenAIRE |
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