Total synthesis of non-natural compounds for molecular recognition. The double challenge

Autor:	J. De Mendoza, Amalia Galán, C. Seel, J. O. Magrans, Enrique Botana, J. Sanchez-Quesada, Armando Salmerón, Guo-Yuan Lu, Margarita Segura, Marta Martı́n-Portugués, Pilar Prados, Victoria Alcázar
Rok vydání:	1997
Předmět:	chemistry.chemical_classification Bicyclic molecule Stereochemistry General Chemical Engineering Biomolecule Total synthesis General Chemistry Transition state chemistry.chemical_compound Molecular recognition chemistry Molecule Guanidine Phosphocholine
Zdroj:	Pure and Applied Chemistry. 69:577-582
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac199769030577
Popis:	Molecular recognition of biomolecules by synthetic receptors requires modular assembly of various components to complement the molecular characteristics (sizes, topologies, and functional groups) of the substrate. A number of receptors for biorelevant molecules containing oxoanions have been assembled from a bicyclic chiral guanidine subunit. Several receptors accelerate or catalyze reactions proceeding through anionic transition states. Among the structures recently prepared, a receptor incorporating a calix(6)arene subunit has been developed, showing high affhity for phosphocholine derivatives. Chains of tetraguanidinium sulfates form double helices in solution. These substances strongly induce formation of a-helical conformations in Asp rich peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::56a77dc1a4e1b513f23aa87cdd4625a5 https://doi.org/10.1351/pac199769030577 Zobrazit plný text záznamu