β-Glucan-enriched fermented barley bran (Sigumjang meju) extracts attenuates gastric mucosal injury induced by acute alcohol intake in vivo
| Autor: | Gi Dong Han, Keuk-Jun Kim, Mihyung Kim, Soohyung Lee, Dongyeop Kim, Hyo Jin Song, Hojeong Jeong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
Meju 030309 nutrition & dietetics medicine.medical_treatment Absorption (skin) Pharmacology Biochemistry 03 medical and health sciences 0404 agricultural biotechnology In vivo mental disorders Gastric mucosa medicine reproductive and urinary physiology Glucan chemistry.chemical_classification 0303 health sciences Chemistry digestive oral and skin physiology FBB 04 agricultural and veterinary sciences 040401 food science digestive system diseases medicine.anatomical_structure Cytokine Fermentation Food Science |
| Zdroj: | Food Bioscience. 28:20-26 |
| ISSN: | 2212-4292 |
| DOI: | 10.1016/j.fbio.2019.01.007 |
| Popis: | Fermented barley bran (FBB) using Bacillus spp. is the main ingredient of sigumjang, a traditional fermented food in South Korea. The aim of this study was to evaluate the gastro-protective effects of β-glucan-enriched FBB extracts in an experimental mouse model of the EtOH-induced gastric ulcer. The gastro-protective activity of FBB was determined using histopathological inspection, level of EtOH absorption from the gastrointestinal-tract and measurement of pro-inflammatory cytokine. Pretreatment of FBB showed less gastrointestinal bleeding and reduced EtOH absorption into the bloodstream with the gastric mucosa. Furthermore, FBB effectively reduced the EtOH-induced mRNA expression of tumor necrosis factor α in the gastric mucosa and its level in the blood. These results showed that FBB can prevent gastric mucosal damage induced by acute EtOH-administration in mice by reducing absorption of EtOH by gastric mucosa along with decreasing the inflammatory response. Altogether, this data provides useful information on how β-glucan-enriched food modulates the EtOH-induced gastric mucosal damage, and thus, it could lead to the development of formulations for protecting gastric mucosal injury with acute alcohol intake. |
| Databáze: | OpenAIRE |
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