Lymphoma and other malignancies in primary Sjogren's syndrome
| Autor: | S R Pillemer |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry Immunology Population medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Lymphoma medicine.anatomical_structure Rheumatology hemic and lymphatic diseases Internal medicine medicine Immunology and Allergy Skin cancer Risk factor education B-cell lymphoma business Mucosa-associated lymphoid tissue CD8 B cell |
| Zdroj: | Annals of the Rheumatic Diseases. 65:704-706 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2005.044362 |
| Popis: | Low peripheral CD4+ counts or low CD4+/CD8+ ratios may be important risk factors for lymphoma in SS Theander et al break new ground with the observation that a low CD4+/CD8+ T lymphocyte ratio is a risk factor for the development of B cell lymphoma in Sjogren’s syndrome (SS) in a longitudinal population based study.1 Also, while the incidence of lymphoma is substantially increased in their patients with SS over that in the general population, it is not as high that described in an initial report in a highly selected population. This increased risk of developing lymphoma was seen only in patients who met the American European classification criteria (AECC) for SS.2 Additionally, Theander et al found that purpura or skin vasculitis, and low C3 and low C4 are associated with the development of haematological malignancy.1 Interestingly, while indolent lymphomas (often of the mucosa associated lymphoid tissue (MALT) type) are more commonly reported in SS, Theander et al found that 58% in their cohort had high grade, diffuse large B cell lymphomas.1 A strength of their study is the use of the Swedish health registers to provide population based data and the availability of a well characterised population of patients with SS. An intriguing, incidental, and tenuous observation, which will require further investigation, is that a history of skin cancer may increase the risk of later developing lymphoma in patients with SS. The interpretation of these findings is discussed here. The findings of Theander et al 1 regarding risk factors for B cell lymphomas in SS2 raise interesting questions. ### Why are patients with SS more prone to B cell lymphomas? In part, the answer relates to the clinical characteristics of the disease, and that lymphocytes, including B cells, are important in SS. SS has been described as an autoimmune exocrinopathy or epitheliitis.3 Lymphocytic infiltration of the … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|