Coexistence of IgM antihepatitis A virus and IgM antihepatitis E virus in acute viral hepatitis: a prospective, multicentre study in Korea
| Autor: | Jung-Sung Kim, Youn Jung, S.-K. Kang, S. J. Park, Sook-Hyang Jeong, H. Yun, Y. M. Park, Seong Gyu Hwang, Jeong Sim Kim, Jeong Whun Kim, Je-Hyuck Jang, Kyu Sung Rim, Seonmin Lee, Hyo-Suk Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Hepatology
biology business.industry viruses virus diseases Hepatitis A medicine.disease Hepatitis E medicine.disease_cause Virology digestive system diseases Virus Serology Infectious Diseases Hepatitis E virus Immunoglobulin M Immunology Coinfection biology.protein Medicine business Viral hepatitis |
| Zdroj: | Journal of Viral Hepatitis. 18:e408-e414 |
| ISSN: | 1352-0504 |
| DOI: | 10.1111/j.1365-2893.2011.01477.x |
| Popis: | Summary. This study investigated the clinical, serological and molecular characteristics of coexistence of both immunoglobulin M (IgM) antihepatitis A virus (HAV) and IgM antihepatitis E virus (HEV) in acute viral hepatitis using a prospective, multicentre design. Among a total of 771 symptomatic cases with acute viral hepatitis enrolled in a Korean city from September 2006 to August 2008, coexistence of IgM anti-HAV and IgM anti-HEV was found in 43 patients (A+E group; 6%), while the existence of IgM anti-HAV alone was found in 595 patients (A group; 77%) and that of IgM anti-HEV alone in 14 patients (E group; 2%). Clinical data analysis and measurement of IgM and IgG anti-HEV were performed using two different commercial kits, and HAV RNA and HEV RNA were detected in available serum or stool samples. The clinical features of the A+E group were similar to those of the A group. HAV RNA detection rates in the A+E and A group were similar, while HEV RNA was detected only in the stool samples of the E group, not in the A+E group. Comparative testing of anti-HEV using two different ELISA kits showed markedly discordant results for IgM anti-HEV positivity and consistently low positivity for IgG anti-HEV in the A+E group. Coexistence of IgM anti-HEV measured by the Genelabs ELISA kit in the setting of hepatitis A appears to yield false-positive results in nonendemic areas of HEV infection. Diagnosis of hepatitis E using IgM anti-HEV should be made with caution. |
| Databáze: | OpenAIRE |
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