The role of Toll: How therapies targeting Toll-like receptors treat skin diseases

Autor:	Jamie E. McInturff, Jenny Kim
Rok vydání:	2006
Předmět:	Pharmacology integumentary system business.industry Retinoic acid Treatment options Imiquimod Tlr agonists chemistry.chemical_compound chemistry Downregulation and upregulation Drug Discovery Immunology medicine Molecular Medicine Receptor business medicine.drug Therapeutic strategy
Zdroj:	Drug Discovery Today: Therapeutic Strategies. 3:75-80
ISSN:	1740-6773
Popis:	Because upregulation of Toll-like receptor (TLR) expression has been observed in some skin diseases, the modulation of TLR function is an elegant therapeutic strategy. The TLR agonist imiquimod has already established utility in treating cutaneous viral pathogens and skin cancers, and all-trans retinoic acid has been shown to downregulate TLR expression. Perhaps the future development of drugs that block TLR activation might provide new treatment options for inflammatory skin diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::569be8212ac6c3acc2c4f3133837474a https://doi.org/10.1016/j.ddstr.2006.02.008 Zobrazit plný text záznamu Full Text from ScienceDirect