Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index
Autor: | Elwin Verheij, Evert de Vries, Vincent van Ginneken, Jan van der Greef |
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Rok vydání: | 2017 |
Předmět: |
Gerontology
medicine.medical_specialty business.industry Pharmaceutical Science Lipid metabolism Human brain Type 2 diabetes medicine.disease Obesity 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Endocrinology 030220 oncology & carcinogenesis Internal medicine Diabetes mellitus medicine Dementia business Body mass index 030217 neurology & neurosurgery Depression (differential diagnoses) |
Zdroj: | Journal of Bioanalysis & Biomedicine. |
ISSN: | 1948-593X |
Popis: | In this study we investigated lipid profiles of brain of post mortem type 2 diabetes patients T2DM elderly patients in comparison to a Control group (Co) of the “Netherlands Brain Bank” using LCMS techniques. Here we report that brains of these T2DM patients contain more double bonds and consequently are more rigid. In a small cohort (≈200 patients) we prove that these brain diseases are not interrelated with BMI so obesity is not a major cause. The predicted wave of brain diseases of mild-Alzheimer (m-AD), dementia and depression of the “baby boom generation” might be evolved due to the “fatty” and more “rigid” brain structure due to the quality of fats eaten during earlier lifespan. Our major conclusion is that diabetes and its treatment among T2DM patients are more associated with structural disturbances (lipid composition) in the brain than with glycaemic control. Therefore we introduce the new terminology “Type 3 diabetes” (T3DM) referring to the mental disorders as a consequence of a disordered lipid metabolism in the human brain related to higher degree of unsaturated fatty acids composition. |
Databáze: | OpenAIRE |
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