| Popis: |
HRAS protein is indispensable cell division regulator, mutated HRAS gene can lead to unregulated cell growth and subsequently cause cancer. In this study, we assembled all 32 complete primate HRAS proteins from the public GenBank database and further characterized them from phylogenetic and proteomic angles. The New World primate HRAS proteins were unravelled to be very greatly conserved in terms of amino acid length, molecular weight and isoelectric point. Motif distribution and predicted protein modelling of all primate HRAS proteins exhibited non-distinctive features. The maximum likelihood phylogenetic tree unearthed two main clades, with seven protein members housing the minor clade. The data produced from this study can channel clues to combat HRAS-related cancers in the future. |
