A GENERAL SYNTHESIS OF NUCLEOSIDES-5′ TRIPHOSPHATES

Autor:	J. G. Moffatt
Rok vydání:	1964
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Organic chemistry General Chemistry Synthesis of nucleosides Molecular sieve Pyrophosphate Catalysis
Zdroj:	Canadian Journal of Chemistry. 42:599-604
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v64-087
Popis:	The reaction between ribo- and deoxyribo-nucleoside-5′ phosphoromorpholidates and tributylammonium pyrophosphate in molecular sieve dried dimethyl sulphoxide has been found to give the nucleoside-5′ triphosphates in 81–84% yields. A convenient work-up of the triphosphates following ion exchange chromatography permits isolation of the triphosphates in overall yields of 73–80% as the pure sodium salts. A number of examples of the reaction are given.
Databáze:	OpenAIRE
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