Multiplex Analysis of the Activation of the Immune System after Transection of the Rat’s Sciatic Nerve
| Autor: | Ekaterina V. Martynova, Galina Masgutova, Albert A. Rizvanov, Ruslan Masgutov, Adelya Mullakhmetova, Liliya Mukhametova, Gulnaz Kadyrova, Svetlana F. Khaiboullina |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty business.industry Leptin Biomedical Engineering Bioengineering Anatomy Sciatic nerve injury medicine.disease 03 medical and health sciences Interleukin 10 030104 developmental biology 0302 clinical medicine Immune system nervous system medicine Interleukin 18 Multiplex IL17A Sciatic nerve business 030217 neurology & neurosurgery |
| Zdroj: | BioNanoScience. 7:170-176 |
| ISSN: | 2191-1649 2191-1630 |
| DOI: | 10.1007/s12668-016-0332-8 |
| Popis: | In this study, using the model of sciatic nerve transection in rats, the cytokine profile of peripheral blood serum and rat sciatic nerve fragments was measured 3, 7 and 14 days after the injury. Histological analysis of sciatic nerve longitudinal sections was carried out at the same periods of time. The cytokine profile of peripheral blood serum of an intact rat as well as the cytokine profile of an intact homogenized sciatic nerve of a rat was examined. Comparative study of changes in quantitative measures before and after the injury was carried out. It was shown that in peripheral blood serum after the sciatic nerve transection, there was a change in quantitative measures of IL1a, Leptin, IL6, MCP1, and MIP2. In the samples of the rat sciatic nerve, the changes were found in the levels of EGF, Fractalkine, GCSF, IFNg, IL10, IL17A, IL18, IL2, IL6, IP10, Leptin, LIX, MCP1, MIP1a, MIP2, and RANTES. |
| Databáze: | OpenAIRE |
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