Synthesis of trifluoromethyl-group-containing cyclopentadienones by the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and trifluoromethyl-group substituted internal alkynes and carbon monoxide
| Autor: | Motoi Kawatsura, Kousuke Iwakami, Shogo Murakami, Hiroaki Tsuji, Taro Sonehara |
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| Rok vydání: | 2019 |
| Předmět: |
Trifluoromethyl
010405 organic chemistry Aryl Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Cycloaddition 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Group (periodic table) Yield (chemistry) Drug Discovery Palladium Carbon monoxide |
| Zdroj: | Tetrahedron Letters. 60:598-601 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2019.01.036 |
| Popis: | We investigated the palladium-catalyzed [2 + 2 + 1] cycloaddition of aryl- and trifluoromethyl-group-substituted internal alkynes and carbon monoxide, and revealed that the PdBr2 effectively catalyzed the intended reaction. The PdBr2-catalyzed reaction smoothly proceeded and provided aryl- and trifluoromethyl-group-containing cyclopentadienone derivatives in up to 92% yield. |
| Databáze: | OpenAIRE |
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