Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor1
| Autor: | Sergio P. A. Toledo, Rossana M. C. Pereira, C Y Hayashida, Rogério G. Gondo, Norma L. Santos, Michael A. Levine, N M A Abelin, Cyril Y. Bowers, Roberto Salvatori, Anita H. O. Souza, Manuel H. Aguiar-Oliveira |
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| Rok vydání: | 2001 |
| Předmět: |
endocrine system
medicine.medical_specialty Pituitary gland Growth-hormone-releasing hormone receptor Somatotropic cell Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Biology Biochemistry Growth hormone secretion Endocrinology medicine.anatomical_structure Hypothalamus Hormone receptor Internal medicine medicine Receptor hormones hormone substitutes and hormone antagonists Hydrocortisone medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 86:3279-3283 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.86.7.7694 |
| Popis: | GH-releasing peptides (GHRPs) are synthetic peptides that bind to specific receptors and thereby stimulate the secretion of pituitary GH. In vivo it is uncertain whether these peptides act directly on somatotroph cells or indirectly via release of GHRH from the hypothalamus. In this study we compared the pituitary hormone response to GHRP-2 in 11 individuals with isolated GH deficiency (GHD) due to a homozygous mutation of the GHRH receptor (GHRH-R) gene and in 8 normal unrelated controls. Basal serum GH levels were lower in the GHD group compared with controls [0.11 +/- 0.11 (range |
| Databáze: | OpenAIRE |
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