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Background: Hyperuricemia is one of the well-known cardiovascular risk factors. In recent studies, hyperuricemia has been shown to be an independent risk factor for atrial fibrillation, which may be associated with oxidative stress or inflammation. There is still a lack of data on the association of hyperuricemia and arrhythmia other than atrial fibrillation. Objectives: In this study, we investigated the relationship between hyperuricemia and heart rate (HR) irregularity using representative sample data of adult Korean. Methods: The study included 5870 subjects aged 19 years or older who completed the uric acid measurement in the Korean National Health and Nutrition Examination Survey conducted in 2016. Logistic regression was used to analyze the association between hyperuricemia and HR irregularity identified by the examiner at the time of the survey. Results: Subjects with HR irregularity were older, had more smoking and drinking, had a higher prevalence of HTN, and had lower glomerular filtration rate than those with regular heartbeat. In the presence of hyperuricemia, the HR irregularity was three times higher than in the absence (HR 3.65, 95% CI 1.77-7.53, P = 0.0005). The association of HR irregularity and hyperuricemia was significant in most subjects, especially in those older than 65 years, with diabetes and hypertension. Conclusion: Hyperuricemia was highly correlated with HR irregularity in adult Korean representative sample data, especially in subjects with conventional cardiovascular risk factors such as old age, hypertension, diabetes mellitus. This study included all subjects who showed HR irregularity at the time of examination, not just atrial fibrillation. Therefore, it is suggested that hyperuricemia may be associated with other arrhythmia as well as atrial fibrillation. Further researches are warranted to clarify the relationship between hyperuricemia and arrhythmia and its mechanism. Disclosure of Interests: None declared |
