Blast transformation of lymphocytes and the activity of natural killer cells in the presence of γ-globulinin vitro

Autor:	I. A. Tarkhanova, E. E. Babaeva, S. B. Cheknev, Ya. G. Ashmanova, A. Ya. Kul'berg
Rok vydání:	1994
Předmět:	Blast transformation Lymphokine-activated killer cell Chemistry Immunology γ globulin Cytotoxic T cell General Medicine Natural killer T cell Molecular biology General Biochemistry Genetics and Molecular Biology In vitro
Zdroj:	Bulletin of Experimental Biology and Medicine. 118:1317-1321
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445740
Popis:	The cytotoxic activity of natural killer cells against3H-uridine-labeled target cells (human erythromyeloleukosis cells K-562) and the intensity of spontaneous blast transformation are studiedin vitro in the presence of human serum γ-globulin. It is shown that spontaneous blast transformation is 49–51% due to the presence of aggregated γ-globulin, while the aggregate-free γ-globulin fraction does not induce this reaction. The cytotoxic activity of natural killer cellsin vitro declines in the presence of native γ-globulin, which is related to the influence of aggregated γ-globulin, the intensity of whose formation may increase upon a manyfold decrease in the γ-globulin content of the preparation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5657d0bdf7fce05a9568961683cc6b77 https://doi.org/10.1007/bf02445740 Zobrazit plný text záznamu Full text from SpringerLink