D-lactic acidemia and aciduria in pediatric and adult patients with short bowel syndrome

Autor:	René S. V. M. Severijnen, G.P.A. Bongaerts, Ton H. J. Naber, Hans L. Willems, Jules J. M. Tolboom, J Bakkeren
Rok vydání:	1995
Předmět:	medicine.medical_specialty Adult patients business.industry Urinary system Biochemistry (medical) Clinical Biochemistry Metabolic disorder Urine medicine.disease Short bowel syndrome Gastroenterology Pathogenesis Excretion Endocrinology Internal medicine medicine medicine.symptom business Acidosis
Zdroj:	Clinical Chemistry. 41:107-110
ISSN:	1530-8561 0009-9147
DOI:	10.1093/clinchem/41.1.107
Popis:	D-Lactate produced by abundant intestinal lactobacilli during acidotic episodes in short bowel (SB) patients is commonly regarded as a main factor in the pathogenesis of SB syndrome-associated (D-lactic) acidosis. Since we had observed that gram-positive bacteria, mainly lactobacilli, were abundant even in the absence of acidosis, we studied serum concentrations and urinary excretions of D- and L-lactate in young and adult SB patients, especially during nonacidotic periods. Serum L-lactate and urinary L-lactate excretion were similar in adults and children. Serum D-lactate and urinary D-lactate excretion were higher in SB children than in SB adults. Food consumption affects D-lactate production and alters D-lactic acidemia and aciduria. We conclude that D-lactate is frequently present in serum of SB patients even in the absence of acidosis. High serum concentrations and urinary excretions may reflect dietary factors in these patients.
Databáze:	OpenAIRE
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