Effects of Anaesthetic Protocol on Kidney and Liver Function of Female Dogs undergoing Ovariohysterectomy
| Autor: | Rajesh Kumar, A.K. Das, Aakanksha ., N.K. Verma, Aakash ., A.C. Saxena, M. Hoque |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Indian Journal of Animal Research. |
| ISSN: | 0976-0555 0367-6722 |
| DOI: | 10.18805/ijar.b-4862 |
| Popis: | Background: Nearly all anaesthetic agent decreases renal and hepatic blood flow, so anaesthetic agents should be selected properly in patients particularly with pre-existing renal and hepatic impairment. The present study conducted to evaluate the effect of acepromazine, midazolam and dexmedetomidine as pre-anaesthetic agent followed by induction with propofol and maintenance with isoflurane on kidney and liver function of client-owned female dogs undergoing elective ovariohysterectomy. Methods: Thirty-two clinically healthy female dogs were randomly divided into four groups with ten animals in the groups A and B and six animals in groups C and D for elective ovariohysterectomy. Animals were premedicated with acepromazine-butorphanol in group A, midazolam-butorphanol in group B, dexmedetomidine (I/M)- butorphanol in group C and dexmedetomidine (I/V)- butorphanol in group D. Animals in all four groups were induced (till effect) with propofol and maintained with isoflurane. Result: All the groups showed non-significant marginal decline in BUN and serum creatinine at 5 minutes after pre-medication. Serum AST and ALT were non-significant decreased in groups A and B and non-significant increase in groups C and D during observations. Serum albumin and globulin gradually but non-significantly decrease in group A after premedication to T20 during anesthesia with isoflurane, then gradually increase upto extubation, but values remained lower in comparison to base values. |
| Databáze: | OpenAIRE |
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