Gamma-Aminobutyric Acid-B (GABAB) Binding Sites in Postmortem Suicide Brains
| Autor: | Jan Marcusson, Antonina Eriksson, B. Arranz, R. Cowburn, M. Vestling |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
Frontal cortex Carbon monoxide poisoning Central nervous system Poison control medicine.disease Suicide prevention gamma-Aminobutyric acid Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology medicine.anatomical_structure nervous system Anesthesia Internal medicine medicine Binding site Psychology Biological Psychiatry Depression (differential diagnoses) medicine.drug |
| Zdroj: | Neuropsychobiology. 26:33-36 |
| ISSN: | 1423-0224 0302-282X |
| DOI: | 10.1159/000118893 |
| Popis: | Gamma-aminobutyric acid-B (GABAB) binding sites labelled with [¾]GABA were determined in postmortem frontal cortex samples of 20 control subjects and 16 suicides. The suicide group was further subdivided according to the method of suicide and the existence of depressive symptoms prior to death. No significant differences in GABAB binding were found either between overall suicide and control groups or between the control group and the other subgroups (violent suicide, nonviolent suicide, nondepressed and depressed suicide victims). A significant increase in GABAB binding was observed in those individuals dying from carbon monoxide poisoning. It is concluded that although GABAB binding sites are not altered in our suicide group, a presyn-aptic dysfunction might account for the increased GABAB binding found in the carbon monoxide subgroup. |
| Databáze: | OpenAIRE |
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