HYPOVITAMINOSIS D IN THAILAND WAS ASSOCIATED WITH DECREASED RISK FOR HYPERTENSION: PP.7.274
| Autor: | Ammarin Thakkinstian, Piyamitr Sritara, L Chailurkit, K Sumriddetchkajorn |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
biology Triglyceride Physiology business.industry Stepwise regression Serum concentration Thais biology.organism_classification medicine.disease vitamin D deficiency chemistry.chemical_compound Endocrinology Hypovitaminosis chemistry Internal medicine Internal Medicine medicine Vitamin D and neurology Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Journal of Hypertension. 28:e131-e132 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/01.hjh.0000378598.53763.49 |
| Popis: | Background: Low serum concentration of 25-hydroxyvitamin D [25(OH)D] is associated with hypertension. Hypovitaminosis D has been observed in tropical regions, its association with hypertension is unknown. Objective: The purpose of this study was to explore the existence of hypovitamnosis D and its association with hypertension in Thailand. Design: A matched nested case-control study was conducted on participants from a cardiovascular study. Serum 25(OH) D concentrations in 1985 from randomly selected 137 cases and controls were used to determine vitamin D status and calculate the odd ratios (OR) of having hypertension in 1997. Serum 25(OH)D ≤ 28 ng/dL was used as a cutoff value. Cases and controls were matched for age and gender. Body mass index (BMI), HDL, LDL, triglyceride were used as covariates. Results: 36% of the participants had suboptimal 25(OH)D concentration. Controls had a significantly higher proportion of vitamin D deficiency than cases. Adjusted for matching variables, the odd ratios (OR) of having hypertension were marginally significant for hypovitaminosis D (OR, 0.59; 95%CI, 0.35–0.99; p = .05) but statistically significant for higher BMI (OR, 2.07; 95%CI, 1.12–3.83; p = .02). The OR of having hypertension for hypovitaminosis D was slightly attenuated but remained marginally significant after further adjustment for BMI, HDL and triglyceride (OR, 0.58; 95%CI, 0.34–0.99; p = .05). Stepwise regression identified BMI as the only variable of significance in relation to hypertension. Conclusion: Although not a rarity in Thailand, hypovitamonisis D was associated with decreased risk of hypertension in Thais. |
| Databáze: | OpenAIRE |
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