Short-term Pulmonary Effects of Using an Electronic Cigarette
| Autor: | Vassiliki Evangelopoulou, Panagiotis Behrakis, Marios Kougias, Gregory N. Connolly, Constantine I. Vardavas, Nektarios Anagnostopoulos |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
Lung business.industry Context (language use) Critical Care and Intensive Care Medicine Pulmonary function testing Nitric oxide chemistry.chemical_compound Impulse Oscillometry Airway resistance medicine.anatomical_structure chemistry Anesthesia Exhaled nitric oxide Medicine Respiratory system Cardiology and Cardiovascular Medicine business |
| Zdroj: | Chest. 141:1400-1406 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.11-2443 |
| Popis: | Background: Debate exists over the scientifi c evidence for claims that electronic cigarettes (e-cigarettes) have no health-related ramifi cations. This study aimed to assess whether using an e-cigarette for 5 min has an impact on the pulmonary function tests and fraction of exhaled nitric oxide (F ENO ) of healthy adult smokers. Methods: Thirty healthy smokers (aged 19-56 years, 14 men) participated in this laboratory-based experimental vs control group study. Ab lib use of an e-cigarette for 5 min with the cartridge included (experimental group, n 5 30) or removed from the device (control group, n 5 10) was assessed. Results: Using an e-cigarette for 5 min led to an immediate decrease in F ENO within the experimental group by 2.14 ppb ( P 5 .005) but not in the control group ( P 5 .859). Total respiratory impedance at 5 Hz in the experimental group was found to also increase by 0.033 kPa/(L/s) ( P , .001), and fl ow respiratory resistance at 5 Hz, 10 Hz, and 20 Hz also statistically increased. Regression analyses controlling for baseline measurements indicated a statistically signifi cant decrease in F ENO and an increase in impedance by 0.04 kPa/(L/s) ( P 5 .003), respiratory resistance at 5 Hz by 0.04 kPa/(L/s) ( P 5 .003), at 10 Hz by 0.034 kPa/(L/s) ( P 5 .008), at 20 Hz by 0.043 kPa/(L/s) ( P 5 .007), and overall peripheral airway resistance ( b , 0.042 kPa/[L/s]; P 5 .024), after using an e-cigarette. Conclusions: e-Cigarettes assessed in the context of this study were found to have immediate adverse physiologic effects after short-term use that are similar to some of the effects seen with tobacco smoking; however, the long-term health effects of e-cigarette use are unknown but potentially adverse and worthy of further investigation. CHEST 2012; 141(6):1400–1406 Abbreviations: e-cigarette 5 electronic cigarette; FDA 5 US Food and Drug Administration; F eno 5 fraction of exhaled nitric oxide; IOS 5 impulse oscillometry system; MEF 5 maximal expiratory fl ow; PEF 5 peak expiratory fl ow; ppb 5 parts per billion; R5Hz 5 airway resistance at 5 Hz; R10Hz 5 airway resistance at 10 Hz; R20Hz 5 airway resistance at 20 Hz; Z5Hz 5 airway impedance at 5 Hz |
| Databáze: | OpenAIRE |
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