Identification of predictive marker of prerenal damage in pregnant women with Preeclampsia and women at high risk- A Prospective study conducted in Riyadh,Saudi Arabia
| Autor: | Huda Al-Mayouf, Latifa Al-Otay, Amal Ali Al-Shenefy, Hajera Tabassum, Farah Aziz Khan, Noura Al-Jameil |
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| Rok vydání: | 2014 |
| Předmět: |
Gynecology
Creatinine medicine.medical_specialty Predictive marker Proteinuria business.industry Urine medicine.disease Gastroenterology female genital diseases and pregnancy complications Preeclampsia chemistry.chemical_compound Blood pressure chemistry Internal medicine embryonic structures Medicine medicine.symptom business Prospective cohort study Blood urea nitrogen reproductive and urinary physiology |
| Zdroj: | International Journal of Medical Science and Public Health. 3:186 |
| ISSN: | 2320-4664 |
| DOI: | 10.5455/ijmsph.2013.201120131 |
| Popis: | Background: Preeclampsia is characterized by development of high blood pressure and proteinuria. It affects 5–8% of all pregnancies and is a major contributor to maternal and fetal morbidity and mortality. There is no single test that fulfils all the criteria for a good predictor of preeclampsia and associated renal damage. Aims & Objectives: To evaluate the role of serum and urine biochemical parameters as early predictors of preeclampsia. To investigate the role of BUN: Creatinine ratio in diagnosing preeclampsia and evaluating prognosis of the disease. Material and Methods: In the present prospective study, one hundred and twenty pregnant women divided into three groups: normotensive (control), women at high risk and with preeclampsia were included. Analyses of different biochemical parameters including BUN: Creatinine were carried out. Results: There was significant difference in the mean value of serum uric acid, blood urea nitrogen, creatinine, urinary protein and BUN: Creatinine ratio in preeclampsia group compared to control group (p < 0.001). There was significant difference (p < 0.05) in serum uric acid between control and preeclampsia group. However, there was no significant change in haematocrit, serum creatinine and urine protein between control and high risk group. Conclusion: BUN: Creatinine ratio in pregnant women with preeclampsia and also in high risk group was significantly increased (t = 15.55, p < 0.001 and t = 8.66, p < 0.001 respectively) in comparison to the control group. This index could be useful in evaluating the severity of preeclampsia and could be used as a predictor in prognosis of preeclampsia and subsequent early renal disease. |
| Databáze: | OpenAIRE |
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