| Autor: |
Salome Siavoshi, Ahmed Busnaina, Jaydev R. Upponi, William C. Hartner, Tiziana Musacchio, Asanterabi Malima, Sivasubramanian Somu, Vladimir P. Torchilin, Cihan Yilmaz, Tatyana S. Levchenko |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-238414/v1 |
| Popis: |
Biomarkers are emerging as potentially important diagnostic tools for cancer and many other diseases. However, many current detection systems for suffer from insufficient sensitivity. To address this concern, we developed a highly sensitive biosensor, featuring monoclonal antibody-coated polystyrene nanobeads assembled in the trenches of a microchip, for the detection of cancer biomarkers. These biosensors detected nucleosomes and carcinoembryonic antigen in serum at concentrations of 62.5 and 15.6 pg/mL, respectively. Very low detection limits that suggest such devices might be beneficial for the early detection of tumors and for monitoring of patients in remission. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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