Effects of housing conditions on behaviors and biochemical parameters in juvenile cynomolgus monkeys (Macaca fascicularis)
| Autor: | Hironari Koyama, Shigetoshi Takemoto, Mayuko Kimura, Kiyoshi Morii, Hayato Kaneko, Kaoru Takaura, Atsushi Toyoda, Sou Wada, Yuki Tachibana |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Environmental enrichment General Veterinary chemistry.chemical_element Physiology General Medicine Urine Calcium Biology Acclimatization General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Blood chemistry chemistry Catecholamine medicine Juvenile Animal Science and Zoology 030217 neurology & neurosurgery Feces medicine.drug |
| Zdroj: | Experimental Animals. 68:195-211 |
| ISSN: | 1881-7122 1341-1357 |
| DOI: | 10.1538/expanim.18-0114 |
| Popis: | To investigate the effects of environmental enrichment on laboratory monkeys, we studied behavioral and physiological differences following changes in housing conditions. Ten male and female juvenile cynomolgus monkeys were first housed in pairs for 8 weeks after quarantine/acclimatization (singly housed) and subsequently housed alone for the next 8 weeks. Monkeys were subjected to evaluations of body weight gain, stereotypic or affiliative behaviors, cortisol, 4-ethylphenyl sulfate (4EPS) and catecholamine concentrations in biological samples, and blood chemistry tests under both housing conditions. Under paired housing, the stereotypic behavioral score decreased in both sexes, and the affiliative behavioral score increased in males and showed an increasing trend in females. Under single housing, the stereotypic score increased in both sexes, and the affiliative score decreased in males. Paired housing decreased serum calcium and urine cortisol concentrations in both sexes and decreased plasma cortisol in males and plasma 4EPS concentrations in females. The stereotypic score was positively correlated with serum calcium, plasma and urine cortisol, and plasma 4EPS concentration and negatively correlated with the affiliative score. The feces painting score, affiliative score, and plasma cortisol and serum calcium concentrations showed sex differences, suggesting differences in responsiveness to environmental changes between males and females. In conclusion, paired housing improved behavioral abnormalities in juvenile cynomolgus monkeys, suggesting that it may be an effective environmental enrichment paradigm. Calcium, cortisol, and 4EPS concentrations in biological samples may be useful indices for evaluating the effects of environmental enrichment. |
| Databáze: | OpenAIRE |
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