Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer
| Autor: | Jiankang Zhang, Limin Kong, Ruoyu He, Yu Cao, Jianjun Xi, Rangxiao Zhuang, Jiaan Shao, Huajian Zhu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pharmacology business.industry Intracellular protein Pharmaceutical Science Cancer medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Proteasome 030220 oncology & carcinogenesis Drug Discovery Cancer research Proteasome inhibitor medicine business Homeostasis Multiple myeloma medicine.drug |
| Zdroj: | Drug Design, Development and Therapy. 14:4327-4342 |
| ISSN: | 1177-8881 |
| DOI: | 10.2147/dddt.s265793 |
| Popis: | Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|