Interventional Effect of Jianpi Bushen Granule Combined with Western Medicine on the Level of Serum Acetylcholine Receptor Antibodies in Myasthenia Gravis Patients
| Autor: | Chao Jiang, Wenjing Bao, Shaobo Qiu, Jing-Sheng Zhang, Ping Liu, Lin Jiang, Yan Liang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
biology business.industry Traditional Chinese medicine medicine.disease Gastroenterology Myasthenia gravis Neuromuscular junction Nicotinic acetylcholine receptor medicine.anatomical_structure Complementary and alternative medicine Internal medicine Immunology biology.protein medicine Clinical significance Antibody business Western medicine Acetylcholine receptor |
| Zdroj: | World Journal of Traditional Chinese Medicine. 1:43-47 |
| ISSN: | 2311-8571 |
| DOI: | 10.15806/j.issn.2311-8571.2015.0012 |
| Popis: | Objective: This study is aimed to investigate the clinical significance of regulating effect of Jianpi Bushen Granule (JBG) combined with Western medicine on the level of serum acetylcholine receptor antibodies (AchRAb) in myasthenia gravis (MG) patients, so as to offer a theoretical basis of the targeted therapy with AchRAb. Methods: We detected the level of anti-AchRAb with enzyme linked immunosorbent assay (ELISA) in the sera from 60 cases of MG patients (randomly divided into the trial group 30 cases, control group 30) for before and after treatment 6 months, and the clinical evaluation carried out by the Quantitative score of myasthenia gravis (QMG) for before and after treatment 3,6 months. Results: (1) Comparison of the level of serum AchRAb:All included MG patients, the positive rate of serum AchRAb was about 81.67% (49/60), and the trial group was 83.33% (25/30), the control group was 90% (27/30), and the serum AchRAb levels of the trial group (0.994 ± 0.417) was lower than that of the contral group (1.068 ± 0.358), but there was no significant difference between the two groups before treatment (P > 0.05). After 6 months of treatment, the serum AchRAb levels of the trial group (0.721 ± 0.280) was also significantly lower than that of the contral group (0.907 ± 0.387), and the serum AchRAb levels was decreased dramatically compared with the same group before treatment, there was significant difference between the two groups (P < 0.05). (2)Comparison of QMG scoring:QMG scoring was decreased dramatically in the trial group compared with that of the control group after treatment, there was significant difference (P < 0.05), moreover, the total effective rate in the trial group (50%,86.67%)was significantly higher than those in the control groups (23.33%, 40%) after 3,6 months treatment (P < 0.05). There was also significant difference in the clinical evaluation by the QMG between the two groups before and after treatment. (3) Adverse reactions: no obvious adverse reactions appeared among the two groups. Conclusions: JBG combined with Western medicine therapy on MG by regulating the level of patients’ serum AchRAb shows definite effects, and it is worthy of further studying. Abbreviations:< JBG: Jianpi Bushen Granule; AchRAb: acetylcholine receptor antibodiesin; MG: myasthenia gravis; ELISA: enzyme linked immunosorbent assay; QMG: Quantitative score of myasthenia gravis; AchR: acetylcholine receptor; N2AchRab: nicotinic acetylcholine receptor; TCM: Traditional Chinese Medicine; MuSK: muscle-specific kinase; NMJ: neuromuscular junction |
| Databáze: | OpenAIRE |
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