Review article: in vitro studies of gall-bladder smooth muscle function. Relevance in cholesterol gallstone disease
| Autor: | Piero Portincasa, Francesco Minerva, G. P. Vanberge-Henegouwen, Antonio Moschetta, N. Venneman, Giuseppe Palasciano |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Motility urologic and male genital diseases digestive system Pathogenesis chemistry.chemical_compound fluids and secretions In vivo Internal medicine medicine Pharmacology (medical) Hepatology Cholesterol business.industry Gallbladder digestive oral and skin physiology Gastroenterology Gallstones medicine.disease digestive system diseases medicine.anatomical_structure Endocrinology chemistry Biliary tract medicine.symptom business Muscle contraction |
| Zdroj: | Alimentary Pharmacology & Therapeutics. 14:19-26 |
| ISSN: | 0269-2813 |
| DOI: | 10.1046/j.1365-2036.2000.014s2019.x |
| Popis: | Summary The interplay between contraction and relaxation in the gall-bladder muscularis leads to appropriate gall-bladder emptying and refilling during fasting and in the postprandial state in vivo. Several studies in both human and animal models have focused on cellular and molecular events in the gall-bladder wall in health and disease in vitro. Principal methods to study gall-bladder smooth muscle function include receptor binding studies (at the level of plasmamembranes or histological sections), phase contrast microscopy (at the level of isolated smooth muscle cells), and tensiometry (at the level of smooth muscle strips or the whole gall-bladder). At a very early stage, cholesterol gallstone disease is characterized by exposure of the gall-bladder wall to excess of biliary cholesterol and the cytotoxic effect of the bile salt deoxycholate. On a long-term basis, a form of gall-bladder leiomyopathy develops with defects involving the mechanisms of signal transduction at the level of plasmamembranes. The end-stage result is pathological contraction and/or relaxation of smooth musculature, impaired gall-bladder motility and gall-bladder stasis, all key factors in the pathogenesis of biliary cholesterol crystallization and gallstones. |
| Databáze: | OpenAIRE |
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