Chemical Constituents of the Terrestrial Stems of Ephedra sinica and their PPAR-γ Ligand-Binding Activity

Autor:	Katsunori Miyake, Yukiko Matsuo, Riko Takeuchi, Yoshihiro Mimaki, Hidetoshi Kumata, Mayu Sasaki, Haruhiko Fukaya
Rok vydání:	2020
Předmět:	Ephedra sinica chemistry.chemical_classification ved/biology Stereochemistry Ligand binding assay ved/biology.organism_classification_rank.species Flavonoid Peroxisome proliferator-activated receptor Fractionation Sesquiterpene chemistry.chemical_compound chemistry Glucoside Chemical constituents
Zdroj:	Planta Medica International Open. 7:e12-e16
ISSN:	2509-6656 2509-9264
Popis:	Bioassay-guided fractionation of the MeOH extract of Ephedra sinica terrestrial stems, using a PPAR-γ ligand binding assay, resulted in the isolation of 10 compounds, including one new bisabolane-type sesquiterpenoid (10). The structure of the new compound was determined by extensive spectroscopic analysis, including two-dimensional (2D) NMR. Among the isolated compounds, the sitosterol derivatives (1 and 2), flavonoid glucoside (7), and the new sesquiterpenoid (10), showed significant PPAR-γ ligand-binding activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::562c143d1e4b812c058218819c940764 https://doi.org/10.1055/a-1094-9229 Zobrazit plný text záznamu