The OPTIEK1 study: Design and preliminary results of a Dutch national registry

Autor: J. van der Maten, L.H. Elbouazzaoui, H.J Bogaard, S.A. Mollema, R. Hoekstra, A. Boonstra, H.M. Willemsen, A.P. Van der Weerdt, M.J. Overbeek, W.M. Waskowsky, Wouter Jacobs, Joris W.J. Vriend, Anna Huis in 't Veld, A. Vonk Noordegraaf, Hans P. Grotjohan
Rok vydání: 2016
Předmět:
Zdroj: 4.3 Pulmonary Circulation and Pulmonary Vascular Diseases.
DOI: 10.1183/13993003.congress-2016.pa1881
Popis: Introduction: While signs of pulmonary hypertension (PH) are frequently noted during routine echocardiography, the incidence of different subtypes of PH in Dutch peripheral hospitals is presently unknown. Aims: The Optimizing Pulmonary Hypertension Diagnostic Network 1 (OPTIEK1) study aims to (1) gain insight in the incidence of subtypes of PH and referral patterns in a non-referral setting and to (2) obtain an external validation cohort for a recently validated risk-score to predict group 2 PH (Jacobs et al. Eur Respir J 2015; 46:422-430). Methods: This is a national, prospective, multi-center registry, collecting clinical data from adult PH cases in non-referral hospitals. All incident patients with suspected or confirmed PH (diagnosed by echocardiography or during right heart catheterization (RHC)) without a LVEF Results: After a pilot phase, the network currently comprises of 11 participating hospitals. 97 patients are included and group 2 PH accounts for the largest group (57%). At diagnosis, mean age is 72 years, 35% of patients are male and most patients are in NYHA functional class II/III (73%). In 24% of the patients a RHC was performed, confirming the presence of precapillary PH in 54% and combined pre- and postcapillary-PH in 10%. Conclusion: This study will provide epidemiological and clinical data of patients with newly diagnosed PH in a non-referral setting. This registry will provide a unique cohort to be used for both the improvement of referral patterns as well as for (future) research purposes.
Databáze: OpenAIRE