| Popis: |
There are few studies reporting the combined use of hormones and non-hormonal agents. In addition, in vitro methods are now available to predict the effectiveness of oestrogens, fluorouracil, methotrexate and adriamycin. We wished to undertake a trial of methotrexate, adriamycin, fluorouracil, and oestrogen in patients with breast cancer following determination of their cellular predictive indices. However, it was first necessary to determine the tolerability of the drug regimen. This paper reports the results of our preliminary phase I trial. |
