P0661 / #2110: STAPHYLOCOCCUS AUREUS NECROTIZING PNEUMONIA: A DIFFERENTIAL DIAGNOSIS OF COVID-19 IN PEDIATRIC POPULATION
| Autor: | D. Doughmi, M. A. Berdai, S. Benlamkadem, M. Harandou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Septic shock Retrospective cohort study Critical Care and Intensive Care Medicine medicine.disease medicine.disease_cause Intensive care unit law.invention Pneumonia Respiratory failure Staphylococcus aureus law Internal medicine Pediatrics Perinatology and Child Health Emerging infectious disease Medicine Septic arthritis business |
| Zdroj: | Pediatric Critical Care Medicine. 22:319-319 |
| ISSN: | 1529-7535 |
| Popis: | AIMS & OBJECTIVES: The aim of the study was to describe the emergence of cases of severe staphylococcus aureus necrotizing pneumonia in the COVID-19 pandemic era and to differentiate between the clinical, biological and radiological presentation of both entities. METHODS: It's a retrospective study during two mounths in a hospital that admit pediatric COVID-19 cases. We included patients diagnosed with staphylococcus aureus necrotizing pneumonia admitted to the intensive care unit. RESULTS: 4 patients were included with a mean age of 13 years old. All of them were suspected initially of COVID-19, this diagnosis has been ruled out by negative RT-PCR of SARSCOV2. They all were previously healty and had an influenza-like prodrome, who progress to septic shock and respiratory failure. Two children presented septic arthritis. Blood cultures were always positives to methicillin sensitive staphylococcus aureus. The RT-PCR for the gene encoding the Panton-Valentine leukocidin (PVL) was positive in one case and is in progress for the others due to unavailability in our institution. Chest-CT revealed always bilateral pneumonias with disseminated nodules, it's associated with pleural effusions in 2 cases. The laboratory finding revealed thrombocytopenia 84100+/-24900/μL, hyperleucocytosis 20800+/-7400/μL and elevated CRP 327+/-51 mg/dL. All the patients were under norepinephrine infusion, three of them needed invasive ventilation. The fatal outcome was deplored in two cases. CONCLUSIONS: Staphylococcus aureus is a rare cause of severe pneumonia that can be confused with COVID-19. It's associated with a high case mortality especially the PVL strain. Despite COVID-19 pandemic, the medical staff attention should also be focused on other emerging infectious disease. |
| Databáze: | OpenAIRE |
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