Repetitive transcranial magnetic stimulation in major depression
| Autor: | Carl Johan Ekman, Mats Adler, Ullvi Båve, Kristoffer Johansson, Johan Lundberg |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment General Medicine medicine.disease law.invention Transcranial magnetic stimulation 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Sample size determination law 030220 oncology & carcinogenesis Montgomery–Åsberg Depression Rating Scale Physical therapy Medicine Major depressive disorder Antidepressant 030212 general & internal medicine business Adverse effect Depression (differential diagnoses) |
| Zdroj: | Medicine. 100:e25273 |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Background The optimal dose (number of pulses per session) of repetitive transcranial magnetic stimulation (rTMS), using the H-coil, in major depressive disorder (MDD) has not previously been reported. Objective To explore the relationship between rTMS dose and antidepressant effect, and collect data for the design of a definitive trial. Methods This was a double-blind, three-arm parallel-group, randomized [1:1:1], pilot trial conducted in Stockholm, Sweden (September 2014 to September 2016). The primary outcome was change in depression severity measured with the Montgomery Asberg Depression Rating Scale (MADRS) after 4 weeks. Participants (n = 29) with MDD were randomized to 1000, 2000, or 4000 pulses of rTMS for 20 sessions during 4 weeks. Results At 4 weeks, the 3 treatment groups reduced the mean MADRS (95% CI) by 11.6 (4.0-19.2), 9.1 (5.0-13.3), and 11.3 (4.1-18.5) points respectively. Eleven participants met criteria for response and 10 for remission. No serious adverse events occurred. Ratings of subjective memory improved in all groups. Exploring the effect of dose and time, 4000 pulses had the largest reduction in MADRS during the first 2 weeks. A comparison of change in MADRS between 2000 and 4000 pulses after 2 weeks will require a sample size of 66 patients at power .80 and alpha .05. Conclusions It is feasible to conduct a definitive trial investigating whether a higher number of magnetic pulses per treatment session gives a more rapid antidepressive response. |
| Databáze: | OpenAIRE |
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