Neutrophil/lymphocyte ratio as a mortality predictor following coronary artery bypass graft surgery
| Autor: | Ahmet Baris Durukan, Emre Kubat, Elif Durukan, Okan Yurdakök, Ertekin Utku Ünal, Cemal Levent Birincioğlu, Anil Ozen, Sinan Sabit Kocabeyoğlu |
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| Rok vydání: | 2013 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Univariate analysis business.industry Lymphocyte Hasta Cabg surgery Independent predictor Surgery medicine.anatomical_structure Baseline characteristics medicine Cardiology and Cardiovascular Medicine business Inflammatory biomarker Artery |
| Zdroj: | Turkish Journal of Thoracic and Cardiovascular Surgery. 21:588-593 |
| ISSN: | 1301-5680 |
| Popis: | Amac: Bu calismada yeni gelistirilen bir enflamatuvar parametre olan notrofil/lenfosit oraninin koroner arter baypas greft (KABG) cerrahisi sonrasi erken donem mortalite prediktoru olarak etkisi arastirildi. Calismaplani:Aralik 2011 Nisan 2012 tarihleri arasinda klinigimizde izole KABG cerrahisi yapilan ardisik 210 hasta prospektif olarak incelendi. Hastalarin baslangic ozellikleri ve ameliyat oncesi notrofil/lenfosit oranlari belirlendi. Ameliyat sonrasi takip suresi 86.1±38.9 gun idi. Primer sonlanim noktasi, tum-nedenlere bagli mortalite olarak belirlendi. Bul gu lar: Dort hastada ameliyat sonrasi ilk 30 gunde olmak uzere, toplam sekiz hastada (%3.8) mortalite goruldu. Tek degiskenli analizlerde ameliyat oncesi notrofil/lenfosit orani, mortalite gelisen ve gelismeyen gruplar arasinda anlamli derecede farkli olarak saptandi (p=0.037). Alici islem karakteristikleri (ROC) egrisinde notrofil/lenfosit orani icin esik degeri 2.81 olarak belirlendi (AUC=0.72, duyarlilik: %75, ozgulluk: %67). Iki grup arasinda anlamli farka sahip olan degiskenler ile yapilan lojistik regresyon analizinde ise, notrofil/lenfosit orani icin esik degerinin uzerinde olmasi mortalite icin bagimsiz bir prediktor olarak saptandi (OR 6.47, %95 CI 1.18-35.38, p=0.031). Sonuc:Kolay bir sekilde hesaplanabilen notrofil/lenfosit orani KABG cerrahisi sonrasi erken donem mortaliteyi ongormede bagimsiz bir faktor olarak kullanilabilir. Anah tar soz cuk ler: Koroner arter baypas greftleme; lenfosit; mortalite; notrofil. Background: In this study, we aimed to investigate the newly introduced inflammatory biomarker, neutrophil/ lymphocyte ratio, as a mortality predictor following coronary artery bypass graft (CABG) surgery. Methods: Between December 2011 and April 2012, 210 consecutive patients who underwent isolated CABG surgery in our clinic were prospectively analyzed. The baseline characteristics of the patients and preoperative neutrophil/ lymphocyte ratio were determined. The postoperative follow-up was 86.1±38.9 days. The primary endpoint was all-cause mortality. Results:Eight patients (3.8%) died of whom four deaths occurred during the first 30 days of follow-up. Univariate analyses revealed a significant difference in the preoperative neutrophil/lymphocyte ratio between the groups in which mortality was seen and the group in which no mortality was observed (p=0.037). The Receiver operating characteristic (ROC) curve showed a threshold value of 2.81 for neutrophil/lymphocyte ratio (AUC=0.72, sensitivity: 75%, specificity: 67%). Logistic regression analysis of the variables with significant differences between two groups revealed that the neutrophil/lymphocyte ratio over its threshold value was an independent predictor for mortality (OR 6.47, 95% CI 1.18-35.38, p=0.031). Conclusion: Neutrophil/lymphocyte ratio, which can be easily calculated, can be used as an independent factor in predicting early mortality following CABG surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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