TBARs and non-enzymatic antioxidant parameters in Tunisian bipolar I patients
| Autor: | Asma Ezzaher, Wahiba Douki, D. Haj Mouhamed, Anwar Mechri, Lotfi Gaha, Mohamed Fadhel Najjar, Fadoua Neffati |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Bipolar I disorder business.industry Bilirubin Biochemistry (medical) Clinical Biochemistry Population Albumin medicine.disease medicine.disease_cause Gastroenterology Surgery chemistry.chemical_compound chemistry Internal medicine TBARS Medicine Uric acid Hyperuricemia business education Oxidative stress |
| Zdroj: | Immuno-analyse & Biologie Spécialisée. 27:315-324 |
| ISSN: | 0923-2532 |
| Popis: | Summary Aims We aim to investigate the variations of some oxidative stress markers (TBARs, uric acid, bilirubin and albumin) in Tunisian bipolar I patients and to explore the association of these parameters to clinical and therapeutic characteristics of this population. Methods Our study included 90 patients with bipolar I disorder and 92 controls. Uric acid, TBARs, bilirubin and albumin concentrations were determined by enzymatic and colorimetric methods. Results Compared with controls, patients had significantly higher values of uric acid and TBARs and significantly lower values of bilirubin. However, no significant change in albumin values was observed. Furthermore, bipolar I disorder was significantly associated with hyperuricemia (OR, 3.64; 95% CI: 1.96–6.75; P Conclusion Bipolar I disorder was significantly associated with hyperuricemia, hypobilirubin, and hyperTBARs, reflecting the existence of oxidative stress. This risk was significantly associated with treatment by mood stabilizers, the illness episode and duration, and the total number of illness episodes. |
| Databáze: | OpenAIRE |
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