Phase II trial of multiagent chemotherapy combined with Y-90 microsphere selective internal radiation therapy (chemo-SIRT) in patients with colorectal cancer liver metastases

Autor:	D. Breutman, Kenneth Pennington, Seza A. Gulec, J. Wheeler, R. Hostetter, D. Schwartzentruber
Rok vydání:	2008
Předmět:	Oncology Cancer Research medicine.medical_specialty Chemotherapy Colorectal cancer business.industry medicine.medical_treatment Selective internal radiation therapy Disease medicine.disease Surgery Microsphere Radiation therapy Internal medicine Toxicity medicine In patient business
Zdroj:	Journal of Clinical Oncology. 26:15011-15011
ISSN:	1527-7755 0732-183X
Popis:	15011 Background: Concurrent chemotherapy and radiation in colorectal cancer(CRC) can improve outcome of local or regional disease. This study is an attempt to derive a similar benefit using chemotherapy and a novel method of radiation therapy for patients with CRC metastatic to liver. Yttrium-90 (Y-90) microsphere selective internal radiation treament (SIRT) has proven to be a safe and effective mode of radiation delivery technique in patients (pts) with CRCLM as a single modality and with 5-FU and FUDR. This is a phase II trial of Y-90 microspheres and concurrent multiagent chemotherapy for management of CRCLM. This study is designed to measure response using updated methods of measurements based on pet scan and computer modeling as well as common criteria. Assessment of toxicity, especially hepatotoxicity and myelotoxicity, is the second major objective. Methods: 20 patients with disease limited predominantly to the liver were recruited for the study. Pre-treatment studies included a liver-protocol PET...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::5616907f3b89ce6461fb525f3a30526b https://doi.org/10.1200/jco.2008.26.15_suppl.15011 Zobrazit plný text záznamu