| Popis: |
The antioxidant activity of curcumin, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, a natural antioxidant obtained from rhizome of Curcume longa L., and related compounds was measured against lipid peroxidation in various media. Curcumin reacted with stable radicals such as galvinoxyl and N,N-diphenyl-1-picrylhydrazyl, indicating it to possibly serve as a potent hydrogen donor, but no curcumin radical could be observed directly by electron spin resonance spectroscopy. Neither could the radical be spin trapped with a-(4-pyridyl-1-oxide)-N-t-butylnitrone. Curcumin suppressed the oxidation of methyl lineolate in organic homogeneous solution and aqueous emulsions, soybean phosphatidylcholine liposomal membranes, and rat liver homogenate induced by free radicals. Curcumin was a stronger antioxidant than 2,6-di-t-butyl-4-methylphenol. Comparable to isoeugenol, but weaker than 3,4-dihydroxycinnamic acid and 2-t-butyl-4-methoxyphenol |
