| Popis: |
The majority of squamous cell carcinomas of the cervix (60 to 80%) contain human papillomavirus (HPV) 16 or 18 DNA, and infection with these viruses is believed to be a major factor in the pathogenesis of the disease. These tumours tend to retain and actively transcribe HPV early region open reading frames (ORFs). The E6 and E7 proteins have been implicated in tumorigenesis owing to their prevalence in cervical. tumours and cell lines derived from them (Smotkin and Wettstein, 1986; Seedorf et al., 1987), transforming activity in vitro(DiMaio, 1991), and their ability to bind to the product of the tumour suppressor genes p53 and Rb, respectively (Dyson et al., 1989; Werness et al., 1990). |
