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Objective of the study: To the develop standard operative procedures of Bhagandharahara lepa and change the form of Bhagandharahara lepa into the form of the Hydrogel. To comparatively analysis Bhagandharahara lepa and its pharmaceutically modified form of Hydrogel with classical and advanced analytical techniques. Methods: Pharmaceutical study: Bhagandharahara lepa and its modified form as a Hydrogel is prepared with standard household parameters. Analytical study: Comparative analysis of both Bhagandharahara lepa and its modified form as a Hydrogel will be comparatively analysed with suitable physicochemical parameters and advanced instrumental methods of analysis. Results: In Stability evaluation of BHL, classically prepared lepa got decomposed next day with foul smell and become darker mustard field in colour, so lepa (wet form) stability remains within 24 hrs. and here physical and chemical stability of dried form of lepa churna is good throughout 3 months of period and in Stability evaluation of BHG prepared hydrogel Light Ochre in colour with easily spreading and physicochemical parameters also like homogeneity and extrudability, viscosity, pH, irritancy test, melting point within limit there is no any major changes throughout the stability period 3 months. So Bhagandharahara Hydrogel is almost remained stable till 3 months. Conclusions: As lepa is having shorter shelf life, it cannot be preserved to longer time, so in this study its modification to Hydrogel form facilitates a longer shelf life. Due to some special features of Hydrogel like extrudability, spreadability, viscosity, pH, homogeneity it is easy to apply to the target site. |
