| Popis: |
In this research, CMOS-integrable enzyme-free amperometric cholesterol nano-biosensors with nanoporous platinum (Pt) electrodes were designed, fabricated and analyzed. These nano-biosensors were fabricated on silicon substrates for U-health and POC (point of care) system applications by using a nonionic surfactant and electroplating technique. These nano-biosensors worked e ciently at an applied potential of 400 mV and exhibited excellent linearity in the cholesterol concentration range from 10 M to 8 mM. They also showed good temperature tolerance up to 50 C. The fabricated nano-biosensors with a nanoporous Pt working electrode (WE) and a 50m spacing between the WE and the counter electrode (CE), with a nanoporous Pt WE and a 10m spacing between the WE and the CE and with a nanoporous Pt WE/CE with a 50m spacing exhibited the cholesterol sensitivity of 13.03 A/mM cm2, 29.9 A/mM cm2 and 30.95 A/mM cm2, respectively. These nano-biosensors were not a ected by several interference species in blood. |
